Plummer–Vinson Syndrome
(Syn: Patterson–Brown–Kelly Syndrome)
(Syn: Patterson–Brown–Kelly Syndrome)
Definition: A clinical condition characterized by dysphagia, iron-deficiency anaemia, and oesophageal webs.
Clinical Features
Classical Features:
- Dysphagia: Difficulty in swallowing.
- Anaemia: Iron-deficiency type.
- Oral Signs: Glossitis, Angular Stomatitis.
- Nails: Koilonychia (Spooning of nails).
- Gastric: Achlorhydria.
- Mucosa: Atrophy of the alimentary tract mucous membrane.
Epidemiology & Pathology
- Demographics: Predominantly Females past 40 years.
- Pathology: Subepithelial fibrosis in the postcricoid region.
- Diagnosis:
- Barium Swallow: Shows a Web in the postcricoid region.
- Oesophagoscopy: Confirms the web.
Complications
⚠ Malignancy Risk:
It is a Premalignant Condition.
It is a Premalignant Condition.
- 10% of cases develop Postcricoid Carcinoma.
- Also predisposes to carcinoma of: Tongue, Buccal mucosa, Pharynx, Oesophagus, Stomach.
Treatment
1. Medical
- Correct Anaemia: Oral or Parenteral Iron.
- Note: Serum Iron levels are more important than Haemoglobin levels.
- Correct associated B12 and B6 deficiency.
2. Surgical
- Dilatation: Of the webbed area using oesophageal bougies.
📚 Source: ENT Dhingra
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